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The G protein-coupled inwardly rectifying potassium channels (GIRKs) are a family of lipid-gated inward-rectifier potassium ion channels which are activated (opened) by the signaling lipid PIP2 and a signal transduction cascade starting with ligand -stimulated G protein-coupled recegirkptors (GPCRs). [1][2] GPCRs in turn release activated G-protein ...

Four G protein gated inwardly-rectifying potassium (GIRK) channel subunits have been identified in mammals: GIRK1, GIRK2, GIRK3, and GIRK4. The GIRK subunits come together to form GIRK ion channels.

G protein-gated inwardly rectifying potassium (GIRK) channels hyperpolarize neurons in response to activation of girkmany different G protein-coupled receptors and thus control the...

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